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Confocal Laser Scanning Microscopes (LSMs) Upgrade Kits

The Upgrade Kit is an external addition to the LSM and grants easy-to-use, versatile, and comfortable performance without time-consuming adjustments.

The PicoQuant group was founded in 1996 to develop robust, compact, and easy to use time-resolved instrumentation and systems.

Our intention is to offer state-of-the-art technology, which has been co-developed and tested by renowned researchers, at a price affordable to scientific groups and cost sensitive industry.

Confocal Laser Scanning Microscopes (LSMs) are widely used tools in biochemistry, cell biology, and other related life sciences. The capabilities of these microscopes can be further enhanced by using time-resolved techniques, granting following advantages:


LSM Upgrade Kit

Compact FLIM and FCS Upgrade Kit for Laser Scanning Microscopes

Confocal Laser Scanning Microscopes (LSMs) are widely used tools in biochemistry, cell biology, and other related life sciences. The capabilities of these microscopes can be further enhanced by using time-resolved techniques, granting following advantages:


Lifetime FRET for quantitative measurements of FRET efficiency.

Time-resolved imaging reveals environmental parameters such as ion concentrations or pH.

Lifetime measurements are independent from fluorophore concentration.

Separation of molecules with spectrally overlapping emission by lifetime fingerprinting.

Reduced number of needed detectors - one detector is sufficient for simultaneous detection of different fluorophores based on their specific lifetimes by pattern matching.

Discrimination of fluorescence light against elastic and Raman scattering and other background contributions by temporal resolution.

Decay time as a further parameter enhances the accuracy of analytical measurements.


The Upgrade Kit is an external addition to the LSM and grants easy-to-use, versatile, and comfortable performance without time-consuming adjustments. The turn-key setup consists of three major parts: picosecond pulsed excitation, single molecule sensitive detection, and Time-Correlated Single Photon Counting (TCSPC) data acquisition.

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